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KMID : 0350519960490010463
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Journal of Catholic Medical College
1996 Volume.49 No. 1 p.463 ~ p.475
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Fibroblast Response (L 929) on Titanium Manganese Alloy (Ti-Mn6) and Pure-Titanium
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Abstract
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Titanium has been widely used as a dental implant material due to good biocompatibility and high resistance to corrosion. When hydroxyapatite (HA) coated titanium surface is used, early initial healing response has been reported. But, the
predictable
longterm application of HA coatings to titanium surface is very difficult because the thermal expansion coefficient of titanium amounts to only 60% of that of HA. As result, it has been reported that coating problems including cracking, flaking,
scraching or chipping were found and subsequent corrosion of substrate material was developed.
Recently, a new titanium alloy, Ti-Mn6, has been reported to overcome the thermal expansion problem. It has good physical properties, and when coated with HA, there exists a extremely thin, strong and crack-free HA coated layer. But, there has
been
few
studies on its biological behavior.
This study was designed to evaluate the biocomapatibility of titanium and Ti-Mn6. The viability of mouse fibroblast (L 929) i8n density of 0.025, 0.05) and 0.1 mg of these particulate materials were evaluated by neutral red assay method from 3
to
48
hours. And the cellular attachment behaviors on titanium and Ti-Mn6 surface were observed at different time period (1~12 hours) using a scanning electron microscope.
@ES The results were as follows;
@EN 1. There were insignificant changes of cellular viabilities in both materials with the density and time and no significant differences were noticed between the groups (P>0.05).
2. In SEM findings, th4 cells on t6itanium and Ti-Mn6 surface were found to the attached and spreaded more rapidly with times, extending cellular processes and attached to adjacent cells.
In 1 hours, there was no different findings between two groups. After 3 hours, however, Ti-Mn6 showed better cellular attachment to it's surface.
These findings suggested that Ti-Mn6 seemed to favorable cellular attachment comparable to titanium, and Ti-Mn6 could be a possibel candidate as a implant substrate material especially for HA coatings.
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